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别名:HDMX; hdm2; ACTFS; MGC5370; MGC71221应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3). |
| Specification | |
|---|---|
| Aliases | HDMX; hdm2; ACTFS; MGC5370; MGC71221 |
| Entrez GeneID | 4193; |
| Swissprot | Q00987 |
| WB Predicted band size | 95kDa;55kDa(Calculated) |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A phospho specific peptide corresponding to residues surrounding S260 of human MDM2. |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/2000 |
 |
Western blot analysis of extracts of 293 cell line, using phospho-MDM2-S260 antibody. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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