Rabbit Polyclonal Antibody to ME2

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别名:NAD-dependent malic enzyme, mitochondrial, NAD-ME, Malic enzyme 2, ME2
应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq].

Description

This gene encodes a mitochondrial NAD-dependent malic
enzyme, a homotetrameric protein, that catalyzes the oxidative
decarboxylation of malate to pyruvate. It had previously been
weakly linked to a syndrome known as Friedreich ataxia that has
since been shown to be the result of mutation in a completely
different gene. Certain single-nucleotide polymorphism haplotypes
of this gene have been shown to increase the risk for idiopathic
generalized epilepsy. Alternatively spliced transcript variants
encoding different isoforms found for this gene. [provided by
RefSeq].

Specification
Aliases	NAD-dependent malic enzyme, mitochondrial, NAD-ME, Malic enzyme 2, ME2
Entrez GeneID	4200
Swissprot	P23368
WB Predicted band size	65.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This ME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the C-terminal region of human ME2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	ME2 Antibody (C-term) (Cat. #P31116) western blot analysis in mouse NIH-3T3,Neuro-2a cell line lysates (35ug/lane).This demonstrates the ME2 antibody detected the ME2 protein (arrow).
	ME2 Antibody (C-term) (Cat. #P31116)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ME2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.