Rabbit Polyclonal Antibody to MED1

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别名:Mediator complex subunit 1;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.Drane P., Oncogene 15:3013-3024(1997).Yuan C.-X., Proc. Natl. Acad. Sci. U.S.A. 95:7939-7944(1998).Naeaer A.M., Nature 398:828-832(1999).

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.Drane P., Oncogene 15:3013-3024(1997).Yuan C.-X., Proc. Natl. Acad. Sci. U.S.A. 95:7939-7944(1998).Naeaer A.M., Nature 398:828-832(1999).

Specification
Aliases	Mediator complex subunit 1;
Entrez GeneID	5469;
Swissprot	Q15648
WB Predicted band size	170kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human MED1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells, using MED1 antibody P42009.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MED1 antibody P42009.