Rabbit Polyclonal Antibody to MED23

包装: 1G|100G|500G|1KG|100KG

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别名:Mediator of RNA polymerase II transcription subunit 23; Mediator complex subunit 23; CRSP complex subunit 3; Cofactor required for Sp1 transcriptional activation subunit 3; Transcriptional coactivator CRSP130
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Required for transcriptional activation subsequent to the assembly of the preinitiation complex By similarity. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.Wiemann S., Genome Res. 11:422-435(2001).Mungall A.J., Nature 425:805-811(2003).Akoulitchev S., Nature 407:102-106(2000).

Description

Required for transcriptional activation subsequent to the assembly of the preinitiation complex By similarity. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.Wiemann S., Genome Res. 11:422-435(2001).Mungall A.J., Nature 425:805-811(2003).Akoulitchev S., Nature 407:102-106(2000).

Specification
Aliases	Mediator of RNA polymerase II transcription subunit 23; Mediator complex subunit 23; CRSP complex subunit 3; Cofactor required for Sp1 transcriptional activation subunit 3; Transcriptional coactivator CRSP130
Entrez GeneID	9439;
Swissprot	Q9ULK4
WB Predicted band size	150kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human MED23.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from A549 cells, using MED23 antiobdy P42140.
	Immunofluorescence analysis of A549 cells, using MED23 antibody P42140.
	Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MED23 antibody P42140.