Rabbit Polyclonal Antibody to MEF2C (Ab-396)

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别名:Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C;
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture By similarity. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).

Description

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture By similarity. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).

Specification
Aliases	Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C;
Entrez GeneID	4208;
Swissprot	Q06413
WB Predicted band size	51kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized non-phosphopeptide derived from human MEF2C around the phosphorylation site of serine 396 (P-V-S(p)-P-P).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000

	Western blot analysis of extracts from 3T3 cells, treated with starved (24hours), using MEF2C (Ab-396) antibody P41757.
	Western blot analysis of extracts from 3T3 cells (Lane 2), using MEF2C (Ab-396) antiobdy P41757. The lane on the left is treated with synthesized peptide.