Rabbit Polyclonal Antibody to MER/SKY (Phospho-Tyr749/681)

包装: 1G|100G|500G|1KG|100KG

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别名:C-mer; MERK; MERTK;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). Graham D.K., Cell Growth Differ. 5:647-657(1994)Gal A., Nat. Genet. 26:270-271(2000)Hillier L.W., Nature 434:724-731(2005).

Description

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). Graham D.K., Cell Growth Differ. 5:647-657(1994)Gal A., Nat. Genet. 26:270-271(2000)Hillier L.W., Nature 434:724-731(2005).

Specification
Aliases	C-mer; MERK; MERTK;
Entrez GeneID	10461;
Swissprot	Q12866
WB Predicted band size	97kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 749/681(K-I-Y(p)-S-G) derived from Human MER/SKY .
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from 3T3 cells treated with EGF using MER/SKY (Phospho-Tyr749/681) Antibody P40443.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using MER/SKY (Phospho-Tyr749/681) antibody P40443 (left)or the same antibody preincubated with blocking peptide (right).