Rabbit Polyclonal Antibody to METAP2 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
应用:WB
反应种属:Human
规格：50μl/100μl

Description
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.

Description

This gene is a member of the methionyl aminopeptidase
family and encodes a protein that binds 2 cobalt or manganese ions.
This protein functions both by protecting the alpha subunit of
eukaryotic initiation factor 2 from inhibitory phosphorylation and
by removing the amino-terminal methionine residue from nascent
protein. Increased expression of this gene is associated with
various forms of cancer and the anti-cancer drugs fumagillin and
ovalicin inhibit the protein by irreversibly binding to its active
site. A pseudogene of this gene is located on chromosome 2.

Specification
Aliases	Methionine aminopeptidase 2 {ECO:0000255\|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255\|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255\|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255\|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255\|HAMAP-Rule:MF_03175}, p67 {ECO:0000255\|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255\|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255\|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255\|HAMAP-Rule:MF_03175}
Entrez GeneID	10988
Swissprot	P50579
WB Predicted band size	52.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This METAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human METAP2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

	METAP2 Antibody (N-term) (Cat. #P31461) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the METAP2 antibody detected the METAP2 protein (arrow).
	Western blot analysis of METAP2 (arrow) using rabbit polyclonal METAP2 Antibody (N-term) (Cat. #P31461). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the METAP2 gene.