中文 
别名:N6-adenosine-methyltransferase subunit METTL14, 2.1.1.62, Methyltransferase-like protein 14, METTL14, KIAA1627应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl
| Description |
|---|
| N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5′-[AG]GAC-3′ consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs. |
| Specification | |
|---|---|
| Aliases | N6-adenosine-methyltransferase subunit METTL14, 2.1.1.62, Methyltransferase-like protein 14, METTL14, KIAA1627 |
| Entrez GeneID | 57721 |
| Swissprot | Q9HCE5 |
| WB Predicted band size | 52.2kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This METTL14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-36 amino acids from the human region of human METTL14. |
| Application | |
|---|---|
| WB | 1/2000 |
| IHC | 1/250 |
 |
All lanes : Anti-METTL14 Antibody (N-Term) at 1:2000 dilution Lane 1: HL-60 whole cell lysate Lane 2: A431 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Predicted band size : 52 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
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P34566 staining METTL14 in human testis tissue sections by Immunohistochemistry (IHC-P – paraformaldehyde-fixed, paraffin-embedded sections). Samples were incubated with primary antibody (1/250) for 1 hours at room temperature. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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