Rabbit Polyclonal Antibody to MLPH

包装: 1G|100G|500G|1KG|100KG

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别名:Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, SlaC2-a, Synaptotagmin-like protein 2a, MLPH, SLAC2A
应用:WB
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Description

This gene encodes a member of the exophilin subfamily of
Rab effector proteins. The protein forms a ternary complex with the
small Ras-related GTPase Rab27A in its GTP-bound form and the motor
protein myosin Va. A similar protein complex in mouse functions to
tether pigment-producing organelles called melanosomes to the actin
cytoskeleton in melanocytes, and is required for visible
pigmentation in the hair and skin. A mutation in this gene results
in Griscelli syndrome type 3, which is characterized by a
silver-gray hair color and abnormal pigment distribution in the
hair shaft. Several alternatively spliced transcript variants of
this gene have been described, but the full-length nature of some
of these variants has not been determined.

Specification
Aliases	Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, SlaC2-a, Synaptotagmin-like protein 2a, MLPH, SLAC2A
Entrez GeneID	79083
Swissprot	Q9BV36
WB Predicted band size	65.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This MLPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-569 amino acids from the C-terminal region of human MLPH.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.