Rabbit Polyclonal Antibody to MLTK

包装: 1G|100G|500G|1KG|100KG

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别名:AZK; EC 2.7.11.25; MLTK; MRK-beta; mixed lineage kinase-related kinase
应用:WB,ICC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at ‘Ser-28’.Gotoh I., J. Biol. Chem. 276:4276-4286(2001). Bloem L.J., J. Mol. Cell. Cardiol. 33:1739-1750(2001).Gross E.A., J. Biol. Chem. 277:13873-13882(2002).

Description

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at ‘Ser-28’.Gotoh I., J. Biol. Chem. 276:4276-4286(2001). Bloem L.J., J. Mol. Cell. Cardiol. 33:1739-1750(2001).Gross E.A., J. Biol. Chem. 277:13873-13882(2002).

Specification
Aliases	AZK; EC 2.7.11.25; MLTK; MRK-beta; mixed lineage kinase-related kinase
Entrez GeneID	51776;
Swissprot	Q9NYL2
WB Predicted band size	91kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from C-terminal of human MLTK.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.