Rabbit Polyclonal Antibody to MMP13

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别名:Collagenase 3, 3424-, Matrix metalloproteinase-13, MMP-13, MMP13
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Description

Proteins of the matrix metalloproteinase (MMP) family are
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP’s are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. The protein encoded by this gene
cleaves type II collagen more efficiently than types I and III. It
may be involved in articular cartilage turnover and cartilage
pathophysiology associated with osteoarthritis. The gene is part of
a cluster of MMP genes which localize to chromosome 11q22.3.

Specification
Aliases	Collagenase 3, 3424-, Matrix metalloproteinase-13, MMP-13, MMP13
Entrez GeneID	4322
Swissprot	P45452
WB Predicted band size	53.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This MMP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human MMP13.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
ICC	1/10-1/50

	MMP13 Antibody (Center) (Cat. #P31328) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MMP13 antibody detected the MMP13 protein (arrow).
	Confocal immunofluorescent analysis of MMP13 Antibody (Center)(Cat#P31328) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
	MMP13 Antibody (Center) (Cat. #P31328)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP13 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.