Rabbit Polyclonal Antibody to MMP8

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别名:matrix metallopeptidase 8 (neutrophil collagenase), HNC, CLG1, MMP-8, PMNL-CL
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Specification
Aliases	matrix metallopeptidase 8 (neutrophil collagenase), HNC, CLG1, MMP-8, PMNL-CL
Entrez GeneID	4317;
Swissprot	P22894
WB Predicted band size	53kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide corresponding to a region derived from 122-135 amino acids of human matrix metallopeptidase 8 (neutrophil collagenase)
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/500-1/2000
IHC	1/25-1/100
ELISA	1:2000-1:5000

	Gel: 8% SDS-PAGE Lysate: 40ug 231 cell lysate Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG – H&L (HRP) at 1/5000 dilution Exposure time: 10 seconds
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 31238 (MMP8 Antibody) at dilution 1/45, on the right is treated with the synthetic peptide.