Rabbit Polyclonal Antibody to MNDA (N-term)

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

400-880-2824

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:Myeloid cell nuclear differentiation antigen, MNDA
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Description

The myeloid cell nuclear differentiation antigen (MNDA) is
detected only in nuclei of cells of the granulocyte-monocyte
lineage. A 200-amino acid region of human MNDA is strikingly
similar to a region in the proteins encoded by a family of
interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and
Ifi-203, that are not regulated in a cell- or tissue-specific
fashion. The 1.8-kb MNDA mRNA, which contains an
interferon-stimulated response element in the 5-prime untranslated
region, was significantly upregulated in human monocytes exposed to
interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS,
CRP, and SPTA1. In its pattern of expression and/or regulation,
MNDA resembles IFI16, suggesting that these genes participate in
blood cell-specific responses to interferons.

Specification
Aliases	Myeloid cell nuclear differentiation antigen, MNDA
Entrez GeneID	4332
Swissprot	P41218
WB Predicted band size	45.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This MNDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of human MNDA.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	Western blot analysis of MNDA Antibody (N-term) Pab (Cat. #P30932) pre-incubated without(lane 1) and with(lane 2) blocking peptide in CEM cell line lysate. MNDA Antibody (N-term) (arrow) was detected using the purified Pab.
	MNDA Antibody (N-term) (Cat. #P30932) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	MNDA Antibody (N-term) (Cat. #P30932)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MNDA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.