Rabbit Polyclonal Antibody to MORF4L2

包装: 1G|100G|500G|1KG|100KG

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别名:MRGX; MORFL2
应用:IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
The members of the mortality factor family include mortality factor 4 (MORF4), mortality factor 4 like 1 (MORF4L1), also known as MORF4-related gene 15 (MRG15), and mortality factor 4 like 2 (MORF4L2), also known as MORF-4 related gene X (MRGX). The human MORF4 gene maps to chromosome 4q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. The genes encoding MORF4L1 and MORF4L2 map to chromosomes 15q25.1 and Xq22.2, respectively. MORF4, MORF4L1 and MORF4L2 each contain a C-terminal leucine zipper. An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. MORF4L1 also associates with the histone acetyl transferase MOF. In addition, MORF4, MORF4L1 and MORF4L2 interact with mSin3A and TLE (transducin-like enhancer of split). The MORF/mSin3A/TLE association may repress transcription. In Purkinje cells, MORF4L1 localizes to the dendrites and the nuclei.

Description

The members of the mortality factor family include mortality factor 4 (MORF4), mortality factor 4 like 1 (MORF4L1), also known as MORF4-related gene 15 (MRG15), and mortality factor 4 like 2 (MORF4L2), also known as MORF-4 related gene X (MRGX). The human MORF4 gene maps to chromosome 4q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. The genes encoding MORF4L1 and MORF4L2 map to chromosomes 15q25.1 and Xq22.2, respectively. MORF4, MORF4L1 and MORF4L2 each contain a C-terminal leucine zipper. An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. MORF4L1 also associates with the histone acetyl transferase MOF. In addition, MORF4, MORF4L1 and MORF4L2 interact with mSin3A and TLE (transducin-like enhancer of split). The MORF/mSin3A/TLE association may repress transcription. In Purkinje cells, MORF4L1 localizes to the dendrites and the nuclei.

Specification
Aliases	MRGX; MORFL2
Swissprot	Q15014
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide of human MORF4L2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/25-1/100
ELISA	1/5000-1/10000

The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P06275(MORF4L2 Antibody) at dilution 1/25. (Original magnification: ×200)

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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