Rabbit Polyclonal Antibody to Mouse Abl1

包装: 1G|100G|500G|1KG|100KG

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别名:Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Abl1, Abl
应用:WB,IHC
反应种属:Mouse
规格：50μl/100μl

Description
Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Description

Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Specification
Aliases	Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Abl1, Abl
Entrez GeneID	11350
Swissprot	P00520
WB Predicted band size	122.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Mouse
Immunogen	This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the Central region of mouse Abl1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	Mouse Abl1 Antibody (Center) (Cat. #P31360) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Abl1 antibody detected the Abl1 protein (arrow).
	Mouse Abl1 Antibody (Center) (P31360)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse duodenum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Abl1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.