Rabbit Polyclonal Antibody to Mouse Dnmt3L

包装: 1G|100G|500G|1KG|100KG

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别名:DNA (cytosine-5)-methyltransferase 3-like, Dnmt3l
应用:WB
反应种属:Human, Mouse
规格：50μl/100μl

Description
mDnmt3L (DNA methyltransferase 3L) does not appear to be catalytically active due to loss of the critical active site residues. It may function not directly as a DNA methyltransferase but rather as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. The protein is well-express in testis, thymus, ovary, and heart. mDnmt3L, which belongs to the 5-cytosine methyltransferase family, contains 1 ADD-type zinc finger.

Description

mDnmt3L (DNA methyltransferase 3L) does not appear to be catalytically active due to loss of the critical active site residues. It may function not directly as a DNA methyltransferase but rather as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. The protein is well-express in testis, thymus, ovary, and heart. mDnmt3L, which belongs to the 5-cytosine methyltransferase family, contains 1 ADD-type zinc finger.

Specification
Aliases	DNA (cytosine-5)-methyltransferase 3-like, Dnmt3l
Entrez GeneID	54427
Swissprot	Q9CWR8
WB Predicted band size	48.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-421 amino acids from mouse Dnmt3L.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Application
WB	1/1000

	Western blot analysis of Mouse Dnmt3L Antibody (Cat. #P30027) in Hela cell line lysates (35ug/lane). Dnmt3l (arrow) was detected using the purified Pab.
	Dnmt3l Antibody (C403) (Cat. #P30027) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Dnmt3l antibody detected the Dnmt3l protein (arrow).