Rabbit Polyclonal Antibody to Mouse Erbb4

包装: 1G|100G|500G|1KG|100KG

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别名:Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4, Erbb4, Mer4
应用:WB
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. The C-terminal fragment (CTF) of isoform JMA-A CYT-2 (containing E4ICD2) can stimulate transcription in the presence of YAP1. ERBB4 intracellular domain is involved in the regulation of cell growth. Conflicting reports are likely due at least in part to the opposing effects of the isoform-specific and nuclear-translocated ERBB4 intracellular domains (E4ICD1 and E4ICD2). Overexpression studies in epithelium show growth inhibition using E4ICD1 and increased proliferation using E4ICD2. E4ICD2 has greater in vitro kinase activity than E4ICD1. The kinase activity is required for the nuclear translocation of E4ICD2 (By similarity).

Description

Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. The C-terminal fragment (CTF) of isoform JMA-A CYT-2 (containing E4ICD2) can stimulate transcription in the presence of YAP1. ERBB4 intracellular domain is involved in the regulation of cell growth. Conflicting reports are likely due at least in part to the opposing effects of the isoform-specific and nuclear-translocated ERBB4 intracellular domains (E4ICD1 and E4ICD2). Overexpression studies in epithelium show growth inhibition using E4ICD1 and increased proliferation using E4ICD2. E4ICD2 has greater in vitro kinase activity than E4ICD1. The kinase activity is required for the nuclear translocation of E4ICD2 (By similarity).

Specification
Aliases	Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4, Erbb4, Mer4
Entrez GeneID	13869
Swissprot	Q61527
WB Predicted band size	146.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	This Mouse Erbb4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1160-1188 amino acids from the C-terminal region of mouse Erbb4.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.