Rabbit Polyclonal Antibody to MPP1

包装: 1G|100G|500G|1KG|100KG

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别名:55 kDa erythrocyte membrane protein, p55, Membrane protein, palmitoylated 1, MPP1, DXS552E, EMP55
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.

Description

This gene encodes the prototype of the membrane-associated
guanylate kinase (MAGUK) family proteins. MAGUKs interact with the
cytoskeleton and regulate cell proliferation, signaling pathways,
and intercellular junctions. The encoded protein is an extensively
palmitoylated membrane phosphoprotein containing a PDZ domain, a
Src homology 3 (SH3) motif, and a guanylate kinase domain. This
gene product interacts with various cytoskeletal proteins and cell
junctional proteins in different tissue and cell types, and may be
involved in the regulation of cell shape, hair cell development,
neural patterning of the retina, and apico-basal polarity and tumor
suppression pathways in non-erythroid cells. Multiple transcript
variants encoding different isoforms have been found for this gene.

Specification
Aliases	55 kDa erythrocyte membrane protein, p55, Membrane protein, palmitoylated 1, MPP1, DXS552E, EMP55
Entrez GeneID	4354
Swissprot	Q00013
WB Predicted band size	52.3kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This MPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-327 amino acids from the Central region of human MPP1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	MPP1 Antibody (Center) (Cat. #P30833) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MPP1 antibody detected the MPP1 protein (arrow).
	Western blot analysis of MPP1 (arrow) using rabbit polyclonal MPP1 Antibody (Center) (Cat. #P30833). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MPP1 gene.
	MPP1 Antibody (Center) (Cat. #P30833) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	MPP1 Antibody (C-term) (Cat. #P30833) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MPP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.