Rabbit Polyclonal Antibody to MRCKB

包装: 1G|100G|500G|1KG|100KG

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别名:CDC42-binding protein kinase beta; CDC42BPB; EC 2.7.11.1; MRCK-beta;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.Nakajima D., DNA Res. 9:99-106(2002).Olsen J.V., Cell 127:635-648(2006).Hirosawa M., DNA Res. 6:329-336(1999).

Description

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.Nakajima D., DNA Res. 9:99-106(2002).Olsen J.V., Cell 127:635-648(2006).Hirosawa M., DNA Res. 6:329-336(1999).

Specification
Aliases	CDC42-binding protein kinase beta; CDC42BPB; EC 2.7.11.1; MRCK-beta;
Entrez GeneID	9578;
Swissprot	Q9Y5S2
WB Predicted band size	194kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human MRCKB.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from COLO cells, using MRCKB antibody P42152.
	Immunohistochemistry analysis of paraffin-embedded human brain tissue using MRCKB antibody P42152.