Rabbit Polyclonal Antibody to MRPL24

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别名:39S ribosomal protein L24; mitochondrial precursor; RM24;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein.Kenmochi N., Genomics 77:65-70(2001).Woodfine K., Nature 441:315-321(2006).Ota T., Nat. Genet. 36:40-45(2004).

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein.Kenmochi N., Genomics 77:65-70(2001).Woodfine K., Nature 441:315-321(2006).Ota T., Nat. Genet. 36:40-45(2004).

Specification
Aliases	39S ribosomal protein L24; mitochondrial precursor; RM24;
Entrez GeneID	79590;
Swissprot	Q96A35
WB Predicted band size	32kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human MRPL24.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HUVEC cells, using MRPL24 antibody P42228.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MRPL24 antibody P42228.