中文 
别名:polypeptide 5; KS6A5; MSPK1; RPS6KA5; RLPK应用:WB
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of ‘Ser-1’ of histone H2A. Phosphorylates ‘Ser-10’ of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate ‘Ser-28’ of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).McCoy CE, et al. (2007) Biochem J 402, 491-501 McCoy CE, et al. (2005)Biochem J 387, 507-17 |
| Specification | |
|---|---|
| Aliases | polypeptide 5; KS6A5; MSPK1; RPS6KA5; RLPK |
| Entrez GeneID | 9252; |
| Swissprot | O75582 |
| WB Predicted band size | 90kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of serine 212 (A-Y-S(p)-F-C) derived from Human MSK1. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from NIH-3T3 cells treated with EGF using MSK1 (Phospho-Ser212) antibody P40572.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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