Rabbit Polyclonal Antibody to MTA1(C-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Metastasis-associated protein MTA1, MTA1
应用:WB
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. [provided by RefSeq].

Description

This gene encodes a protein that was identified in a
screen for genes expressed in metastatic cells, specifically,
mammary adenocarcinoma cell lines. Expression of this gene has been
correlated with the metastatic potential of at least two types of
carcinomas although it is also expressed in many normal tissues.
The role it plays in metastasis is unclear. It was initially
thought to be the 70kD component of a nucleosome remodeling
deacetylase complex, NuRD, but it is more likely that this
component is a different but very similar protein. These two
proteins are so closely related, though, that they share the same
types of domains. These domains include two DNA binding domains, a
dimerization domain, and a domain commonly found in proteins that
methylate DNA. The profile and activity of this gene product
suggest that it is involved in regulating transcription and that
this may be accomplished by chromatin remodeling. [provided by
RefSeq].

Specification
Aliases	Metastasis-associated protein MTA1, MTA1
Entrez GeneID	9112
Swissprot	Q13330
WB Predicted band size	80.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	This MTA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-687 amino acids from the C-terminal region of human MTA1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000-1/2000

All lanes : Anti-MTA1 Antibody(C-term) at 1:1000 dilution
Lane 1: Hela whole cell lysate
Lane 2: mouse brain lysate
Lane 3: MCF-7 whole cell lysate
Lane 4: A431 whole cell lysate
Lane 5: NIH-3T3 whole cell lysate
Lane 6: human brain lysate
Lane 7: rat testis lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 81 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

All lanes : Anti-MTA1 Antibody(C-term) at 1:2000 dilution
Lane 1: MCF-7 whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: A431 whole cell lysate
Lane 4: mouse brain lysate
Lane 5: NIH/3T3 whole cell lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 81 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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