Rabbit Polyclonal Antibody to MUTED

包装: 1G|100G|500G|1KG|100KG

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别名:Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog, BLOC1S5, MUTED
应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene.

Description

This gene encodes a component of BLOC-1 (biogenesis of
lysosome-related organelles complex 1). Components of this complex
are involved in the biogenesis of organelles such as melanosomes
and platelet-dense granules. A mouse model for Hermansky-Pudlak
Syndrome is mutated in the murine version of this gene. Alternative
splicing results in multiple transcript variants. Read-through
transcription exists between this gene and the upstream EEF1E1
(eukaryotic translation elongation factor 1 epsilon 1) gene, as
well as with the downstream TXNDC5 (thioredoxin domain containing
5) gene.

Specification
Aliases	Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog, BLOC1S5, MUTED
Entrez GeneID	63915
Swissprot	Q8TDH9
WB Predicted band size	21.6kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This MUTED antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the Central region of human MUTED.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	MUTED Antibody (Center) (Cat. #P30731) western blot analysis in MDA-MB435 cell line lysates (15ug/lane).This demonstrates the MUTED antibody detected MUTED protein (arrow).
	MUTED Antibody (Center) (Cat. #P30731) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the MUTED antibody detected MUTED protein (arrow).
	MUTED Antibody (Center) (Cat. #P30731) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MUTED Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.