Rabbit Polyclonal Antibody to NAE1

包装: 1G|100G|500G|1KG|100KG

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别名:NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer’s disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Description

The protein encoded by this gene binds to the beta-amyloid
precursor protein. Beta-amyloid precursor protein is a cell surface
protein with signal-transducing properties, and it is thought to
play a role in the pathogenesis of Alzheimer’s disease. In
addition, the encoded protein can form a heterodimer with UBE1C and
bind and activate NEDD8, a ubiquitin-like protein. This protein is
required for cell cycle progression through the S/M checkpoint.
Three transcript variants encoding different isoforms have been
found for this gene.

Specification
Aliases	NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1
Entrez GeneID	8883
Swissprot	Q13564
WB Predicted band size	60.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This NAE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human NAE1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	NAE1 Antibody (Center) (Cat. #P31213) western blot analysis in K562,293 cell line lysates (35ug/lane).This demonstrates the NAE1 antibody detected the NAE1 protein (arrow).
	NAE1 Antibody (Center) (Cat. #P31213)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NAE1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.