Rabbit Polyclonal Antibody to NCK2

包装: 1G|100G|500G|1KG|100KG

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别名:Cytoplasmic protein NCK2; GRB4; NCK adaptor protein 2; NCKbeta; Nck-2
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.Susanne Frese, J. Biol. Chem., Jun 2006; 281: 18236 – 18245. Friedhelm Bladt, Mol. Cell. Biol., Jul 2003; 23: 4586 – 4597. Stephan J. Kempiak, J. Biol. Chem., Feb 2005; 280: 5836 – 5842.Min Chen, Mol. Cell. Biol., Nov 2000; 20: 7867 – 7880.

Description

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.Susanne Frese, J. Biol. Chem., Jun 2006; 281: 18236 – 18245. Friedhelm Bladt, Mol. Cell. Biol., Jul 2003; 23: 4586 – 4597. Stephan J. Kempiak, J. Biol. Chem., Feb 2005; 280: 5836 – 5842.Min Chen, Mol. Cell. Biol., Nov 2000; 20: 7867 – 7880.

Specification
Aliases	Cytoplasmic protein NCK2; GRB4; NCK adaptor protein 2; NCKbeta; Nck-2
Entrez GeneID	8440;
Swissprot	O43639
WB Predicted band size	43kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from C-terminal of human NCK2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.