Rabbit Polyclonal Antibody to NCR1

包装: 1G|100G|500G|1KG|100KG

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别名:LY94; CD335; NKP46; NK-p46
应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
Natural killer (NK) cells mediate MHC nonrestricted cytotoxicity. There are many candidate molecules for NK cell recognition structures, including inhibiting and activating receptors. Using a monoclonal antibody capable of triggering NK-mediated lysis, Sivori et al. (1997) identified a cell surface molecule of 46 kD that they termed p46. The molecule lacks N-linked sugars and is expressed on resting and activated NK cells but not on T cells or B cells. In addition to lytic activity, monoclonal antibody-mediated crosslinking induces intracellular calcium increases and cytokine production.

Description

Natural killer (NK) cells mediate MHC nonrestricted cytotoxicity. There are many candidate molecules for NK cell recognition structures, including inhibiting and activating receptors. Using a monoclonal antibody capable of triggering NK-mediated lysis, Sivori et al. (1997) identified a cell surface molecule of 46 kD that they termed p46. The molecule lacks N-linked sugars and is expressed on resting and activated NK cells but not on T cells or B cells. In addition to lytic activity, monoclonal antibody-mediated crosslinking induces intracellular calcium increases and cytokine production.

Specification
Aliases	LY94; CD335; NKP46; NK-p46
Swissprot	O76036
WB Predicted band size	34 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human NCR1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/500-1/2000
IHC	1/50-1/100
ELISA	1/5000-1/10000

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue lysate, Primary antibody: P11636(NCR1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes
	The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11636(NCR1 Antibody) at dilution 1/50. (Original magnification: ×200)