Rabbit Polyclonal Antibody to NDF2

包装: 1G|100G|500G|1KG|100KG

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别名:Neurogenic differentiation factor 2; NeuroD2; NeuroD-related factor; NDRF; NEUROD2
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter By similarity.McCormick M.B., Mol. Cell. Biol. 16:5792-5800(1996). Kitamura T., Biochim. Biophys. Acta 1445:142-147(1999). The MGC Project Team, Genome Res. 14:2121-2127(2004).

Description

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter By similarity.McCormick M.B., Mol. Cell. Biol. 16:5792-5800(1996). Kitamura T., Biochim. Biophys. Acta 1445:142-147(1999). The MGC Project Team, Genome Res. 14:2121-2127(2004).

Specification
Aliases	Neurogenic differentiation factor 2; NeuroD2; NeuroD-related factor; NDRF; NEUROD2
Entrez GeneID	4761;
Swissprot	Q15784
WB Predicted band size	48kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human NDF2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.