Rabbit Polyclonal Antibody to Neuro D (Ab-274)

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别名:Neurogenic differentiation factor 1; NEUROD1; NEUROD;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5′-CANNTG-3′. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.Tamimi R., Genomics 34:418-421(1996).Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996).Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999)

Description

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5′-CANNTG-3′. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.Tamimi R., Genomics 34:418-421(1996).Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996).Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999)

Specification
Aliases	Neurogenic differentiation factor 1; NEUROD1; NEUROD;
Entrez GeneID	4760;
Swissprot	Q13562
WB Predicted band size	36kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human Neuro D around the phosphorylation site of serine 272 (P-L-S(p)-P-P-).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.