Rabbit Polyclonal Antibody to NFATC1

包装: 1G|100G|500G|1KG|100KG

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别名:Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc, NFATC1, NFAT2, NFATC
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Description

The product of this gene is a component of the nuclear
factor of activated T cells DNA-binding transcription complex. This
complex consists of at least two components: a preexisting
cytosolic component that translocates to the nucleus upon T cell
receptor (TCR) stimulation, and an inducible nuclear component.
Proteins belonging to this family of transcription factors play a
central role in inducible gene transcription during immune
response. The product of this gene is an inducible nuclear
component. It functions as a major molecular target for the
immunosuppressive drugs such as cyclosporin A. Five transcript
variants encoding distinct isoforms have been identified for this
gene. Different isoforms of this protein may regulate inducible
expression of different cytokine genes.

Specification
Aliases	Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc, NFATC1, NFAT2, NFATC
Entrez GeneID	4772
Swissprot	O95644
WB Predicted band size	101.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This NFATC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 898-927 amino acids from the C-terminal region of human NFATC1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	NFATC1 Antibody (C-term) (Cat. #P31358) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NFATC1 antibody detected the NFATC1 protein (arrow).
	NFATC1 Antibody (C-term) (P31358)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NFATC1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.