Rabbit Polyclonal Antibody to NFkB-p105(Phospho-Ser893)

包装: 1G|100G|500G|1KG|100KG

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别名:KBF1; NF-kB1; NFkappaB
应用:IHC,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Description

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Specification
Aliases	KBF1; NF-kB1; NFkappaB
Entrez GeneID	4790;
Swissprot	P19838
WB Predicted band size	120kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.891~895 (A-S-S-P-V) derived from Human NFkB-p105.
Formulation	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
IHC	1/50-1/100
ICC	1/100-1/200

	Immunofluorescence staining of methanol-fixed HeLa cells using NF-κB p105 (phospho-Ser893) antibody (P40018 Red).
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NF-κB p105 (phospho-Ser893) antibody (P40018).