Rabbit Polyclonal Antibody to NLRP12 (N-term)

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别名:NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.

Description

This gene encodes a member of the CATERPILLER family of
cytoplasmic proteins. The encoded protein, which contains an
N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain,
and a C-terminus leucine-rich repeat region, functions as an
attenuating factor of inflammation by suppressing inflammatory
responses in activated monocytes. Alternatively spliced transcript
variants encoding distinct isoforms have been described but the
full-length nature of some of these has not been determined.

Specification
Aliases	NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO
Entrez GeneID	91662
Swissprot	P59046
WB Predicted band size	120.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This NLRP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the N-terminal region of human NLRP12.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	NLRP12 Antibody (N-term) (Cat. #P31385) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP12 antibody detected the NLRP12 protein (arrow).
	NLRP12 Antibody (N-term) (P31385)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NLRP12 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.