Rabbit Polyclonal Antibody to NOD1

包装: 1G|100G|500G|1KG|100KG

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别名:Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4, NOD1, CARD4
应用:WB
反应种属:Human, Mouse
规格：50μl/100μl

Description
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5′ UTR have been described, but the full-length nature of these variants has not been determined.

Description

This gene encodes a member of the NOD (nucleotide-binding
oligomerization domain) family. This member is a cytosolic protein.
It contains an N-terminal caspase recruitment domain (CARD), a
centrally located nucleotide-binding domain (NBD), and 10 tandem
leucine-rich repeats (LRRs) in its C terminus. The CARD is involved
in apoptotic signaling, LRRs participate in protein-protein
interactions, and mutations in the NBD may affect the process of
oligomerization and subsequent function of the LRR domain. This
protein is an intracellular pattern-recognition receptor (PRR) that
initiates inflammation in response to a subset of bacteria through
the detection of bacterial diaminopimelic acid. Multiple
alternatively spliced transcript variants differring in the 5′ UTR
have been described, but the full-length nature of these variants
has not been determined.

Specification
Aliases	Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4, NOD1, CARD4
Entrez GeneID	10392
Swissprot	Q9Y239
WB Predicted band size	107.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This NOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 923-951 amino acids from the C-terminal region of human NOD1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

All lanes : Anti-NOD1 Antibody (C-term) at 1:1000 dilution
Lane 1: CCRF-CEM whole cell lysate
Lane 2: NCI-H1299 whole cell lysate
Lane 3: HL-60 whole cell lysate
Lane 4: HT-29 whole cell lysate
Lane 5: SW480 whole cell lysate
Lane 6: Mouse spleen lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 108 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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