Rabbit Polyclonal Antibody to NOS1AP

包装: 1G|100G|500G|1KG|100KG

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别名:Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein, NOS1AP, CAPON, KIAA0464
应用:WB,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.

Description

This gene encodes a cytosolic protein that binds to the
signaling molecule, neuronal nitric oxide synthase (nNOS). This
protein has a C-terminal PDZ-binding domain that mediates
interactions with nNOS and an N-terminal phosphotyrosine binding
(PTB) domain that binds to the small monomeric G protein, Dexras1.
Studies of the related mouse and rat proteins have shown that this
protein functions as an adapter protein linking nNOS to specific
targets, such as Dexras1 and the synapsins. Alternative splicing
results in multiple transcript variants encoding different
isoforms.

Specification
Aliases	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein, NOS1AP, CAPON, KIAA0464
Entrez GeneID	9722
Swissprot	O75052
WB Predicted band size	56.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This NOS1AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human NOS1AP.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
FCM	1/10-1/50

	Western blot analysis of lysate from MCF-7 cell line, using NOS1AP Antibody (Center)(Cat. #P30752). P30752 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
	NOS1AP Antibody (Center) (Cat. #P30752) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.