Rabbit Polyclonal Antibody to NOX4 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:NADPH oxidase 4, 163-, Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, NOX4, RENOX
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.

Description

This gene encodes a member of the NOX-family of enzymes
that functions as the catalytic subunit the NADPH oxidase complex.
The encoded protein is localized to non-phagocytic cells where it
acts as an oxygen sensor and catalyzes the reduction of molecular
oxygen to various reactive oxygen species (ROS). The ROS generated
by this protein have been implicated in numerous biological
functions including signal transduction, cell differentiation and
tumor cell growth. A pseudogene has been identified on the other
arm of chromosome 11. Alternative splicing results in multiple
transcript variants.

Specification
Aliases	NADPH oxidase 4, 163-, Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, NOX4, RENOX
Entrez GeneID	50507
Swissprot	Q9NPH5
WB Predicted band size	66.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This NOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-153 amino acids from the N-terminal region of human NOX4.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	NOX4 Antibody (N-term) (Cat. #P31386) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NOX4 antibody detected the NOX4 protein (arrow).
	NOX4 Antibody (N-term) (P31386)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NOX4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.