Rabbit Polyclonal Antibody to NPR2

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别名:AMDM; ANPb; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B
应用:IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Description

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Specification
Aliases	AMDM; ANPb; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B
Entrez GeneID	4882;
Swissprot	P20594
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthetic peptide corresponding to a region derived from internal residues of human natriuretic peptide receptor 2
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
IHC	1/50-1/200

	Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using P42943 at dilution 1/45.
	Immunohistochemical analysis of paraffin-embedded Human brain cancer tissue using P42943 at dilution 1/45.