Rabbit Polyclonal Antibody to NTNG2

包装: 1G|100G|500G|1KG|100KG

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别名:Lmnt2; NTNG1; LHLL9381; bA479K20.1
应用:WB
反应种属:Human, Mouse
规格：50μl/100μl

Description
Netrin G1 and Netrin G2, also referred to as laminet-1 and laminet-2, are membrane bound axon guidance molecules involved in synaptic formation and maintenance. They comprise a subgroup within the UNC-6/netrin family. Both genes have been associated with schizophrenia involving single nucleotide polymorphisms. They are both expressed in the brain but G1 is most predominantly expressed in the thalamus and G2 is most predominantly expressed in the cortex and hippocampus. These two proteins differ from classical netrins by their failure to bind netrin receptors, the presence of a glycosyl phosphatidylinositol membrane anchor, and the generation of multiple isoforms. Netrin G2 contains one laminin N-terminal domain and three laminin EGF-like domains. It selectively interacts with LRRC4 and this association may mediate cell adhesion. In addition, Netrin G2 is significantly downregulated in bladder transitional cell carcinoma (TCC) and may be a putative tumor suppressor gene.

Description

Netrin G1 and Netrin G2, also referred to as laminet-1 and laminet-2, are membrane bound axon guidance molecules involved in synaptic formation and maintenance. They comprise a subgroup within the UNC-6/netrin family. Both genes have been associated with schizophrenia involving single nucleotide polymorphisms. They are both expressed in the brain but G1 is most predominantly expressed in the thalamus and G2 is most predominantly expressed in the cortex and hippocampus. These two proteins differ from classical netrins by their failure to bind netrin receptors, the presence of a glycosyl phosphatidylinositol membrane anchor, and the generation of multiple isoforms. Netrin G2 contains one laminin N-terminal domain and three laminin EGF-like domains. It selectively interacts with LRRC4 and this association may mediate cell adhesion. In addition, Netrin G2 is significantly downregulated in bladder transitional cell carcinoma (TCC) and may be a putative tumor suppressor gene.

Specification
Aliases	Lmnt2; NTNG1; LHLL9381; bA479K20.1
Swissprot	Q96CW9
WB Predicted band size	60 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human NTNG2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/200-1/1000
ELISA	1/5000-1/10000

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HEPG2 cell lysate, Primary antibody: P06227(NTNG2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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