Rabbit Polyclonal Antibody to Nuclear Receptor NR4A1 (Ab-351)

包装: 1G|100G|500G|1KG|100KG

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别名:Early response protein NAK1; GFRP; GFRP1; HMR; N10
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5′-AAAAGGTCA-3′ By similarity. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.Nakai A., Mol. Endocrinol. 4:1438-1443(1990).Chang C., J. Steroid Biochem. 34:391-395(1989).The MGC Project Team; Genome Res. 14:2121-2127(2004).

Description

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5′-AAAAGGTCA-3′ By similarity. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.Nakai A., Mol. Endocrinol. 4:1438-1443(1990).Chang C., J. Steroid Biochem. 34:391-395(1989).The MGC Project Team; Genome Res. 14:2121-2127(2004).

Specification
Aliases	Early response protein NAK1; GFRP; GFRP1; HMR; N10
Entrez GeneID	3164;
Swissprot	P22736
WB Predicted band size	60kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human Nuclear Receptor NR4A1 around the phosphorylation site of serine 351 (L-P-S(p)-K-P).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from COS-7 cells, using Nuclear Receptor NR4A1 (Ab-351) antibody P41685.
	Western blot analysis of extracts from HepG2 cells (Lane 2), using Nuclear Receptor NR4A1 (Ab-351) antiobdy P41685. The lane on the left is treated with synthesized peptide.
	Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Nuclear Receptor NR4A1 (Ab-351) antibody P41685.