Rabbit Polyclonal Antibody to p13Cas (Ab-410)

包装: 1G|100G|500G|1KG|100KG

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别名:BCAR1; Breast cancer anti-estrogen resistance 1; CRK-ASSOCIATED SUBSTRATE; CRKAS;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 – 37535.Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 – H2863.Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 – 9189.Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 – 6

Description

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 – 37535.Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 – H2863.Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 – 9189.Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 – 6

Specification
Aliases	BCAR1; Breast cancer anti-estrogen resistance 1; CRK-ASSOCIATED SUBSTRATE; CRKAS;
Entrez GeneID	9564;
Swissprot	P56945
WB Predicted band size	130kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized non-phosphopeptide derived from human p130 Cas around the phosphorylation site of tyrosine 410 (G-V-T-A-V).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from NIH/3T3 cells, using p130 Cas (Ab-410) antibody P41637.
	Western blot analysis of extracts from HuvEc cells using p130 Cas (Ab-410) antibody P41637. The lane on the left is treated with synthesized peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p130 Cas (Ab-410) antibody P41637.