Rabbit Polyclonal Antibody to p13Cas (Phospho-Tyr410)

包装: 1G|100G|500G|1KG|100KG

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别名:BCAR1; CRKAS; CRK-ASSOCIATED SUBSTRATE;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 – 37535Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 – H2863Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 – 9189Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 – 6

Description

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 – 37535Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 – H2863Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 – 9189Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 – 6

Specification
Aliases	BCAR1; CRKAS; CRK-ASSOCIATED SUBSTRATE;
Entrez GeneID	9564;
Swissprot	P56945
WB Predicted band size	130kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of tyrosine 410(G-V-Y(p)-A-V) derived from Human p130 Cas .
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from K562 cells (Lane 2) and 3T3 cells (Lane 3), using P130 Cas(Phospho-Tyr410) Antibody P40373. The lane on the left is treated with antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using p130 Cas (Phospho-Tyr410) antibody P40373 (left)or the same antibody preincubated with blocking peptide (right).