中文 
别名:TP53; tumor protein p53; Tumor suppressor p53;应用:IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.Zakut-Houri R., EMBO J. 4:1251-1255(1985)Lamb P., Mol. Cell. Biol. 6:1379-1385(1986)Harlow E., Mol. Cell. Biol. 5:1601-1610(1985) |
| Specification | |
|---|---|
| Aliases | TP53; tumor protein p53; Tumor suppressor p53; |
| Entrez GeneID | 7157; |
| Swissprot | P04637 |
| WB Predicted band size | 43kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of threonine 387(F-K-T(p)-E-G) derived from Human p53. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| IHC | 1/50-1/100 |
 |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Thr387) antibody P40422 (left)or the same antibody preincubated with blocking peptide (right). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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