Rabbit Polyclonal Antibody to p9RSK (Phospho-Thr573)

包装: 1G|100G|500G|1KG|100KG

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别名:KS6A1; p90RSK1; RSK1; RPS6KA1;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206. Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 – 19048. Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 – 1835.

Description

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206. Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 – 19048. Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 – 1835.

Specification
Aliases	KS6A1; p90RSK1; RSK1; RPS6KA1;
Entrez GeneID	6195;
Swissprot	Q15418
WB Predicted band size	95kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of threonine 573(L-M-T(p)-P-C) derived from Human p90 RSK.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody P40381.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p90 RSK (Phospho-Thr573) antibody P40381 (left)or the same antibody preincubated with blocking peptide (right).