Rabbit Polyclonal Antibody to PAICS (N-term)

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别名:Multifunctional protein ADE2, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, AIR carboxylase, AIRC, PAICS, ADE2, AIRC, PAIS
应用:WB,IHC,FCM
反应种属:Human, Mouse
规格：50μl/100μl

Description
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Description

This gene encodes a bifunctional enzyme containing
phosphoribosylaminoimidazole carboxylase activity in its N-terminal
region and phosphoribosylaminoimidazole succinocarboxamide
synthetase in its C-terminal region. It catalyzes steps 6 and 7 of
purine biosynthesis. The gene is closely linked and divergently
transcribed with a locus that encodes an enzyme in the same
pathway, and transcription of the two genes is coordinately
regulated. The human genome contains several pseudogenes of this
gene. Multiple transcript variants encoding different isoforms have
been found for this gene.

Specification
Aliases	Multifunctional protein ADE2, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, AIR carboxylase, AIRC, PAICS, ADE2, AIRC, PAIS
Entrez GeneID	10606
Swissprot	P22234
WB Predicted band size	47.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This PAICS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human PAICS.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	PAICS Antibody (N-term) (Cat. #P31190) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PAICS antibody detected the PAICS protein (arrow).
	PAICS Antibody (N-term) (Cat. #P31190) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the PAICS antibody detected the PAICS protein (arrow).
	PAICS Antibody (N-term) (Cat. #P31190) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
	PAICS Antibody (N-term) (Cat. #P31190)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PAICS Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.