Rabbit Polyclonal Antibody to PAK1 (Phospho-Ser199)

包装: 1G|100G|500G|1KG|100KG

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别名:ADRB2; PAK 1; P65-PAK; P68-PAK;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.Brown J.L., Curr. Biol. 6:598-605(1996)Sells M.A., Curr. Biol. 7:202-210(1997)The MGC Project Team; Genome Res. 14:2121-2127(2004)

Description

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.Brown J.L., Curr. Biol. 6:598-605(1996)Sells M.A., Curr. Biol. 7:202-210(1997)The MGC Project Team; Genome Res. 14:2121-2127(2004)

Specification
Aliases	ADRB2; PAK 1; P65-PAK; P68-PAK;
Entrez GeneID	5058;
Swissprot	Q13153
WB Predicted band size	61kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of Serine 199(T-K-S(p)-V-I) derived from Human PAK1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from LOVO cells treated with starved using PAK1/2 (Phospho-Ser199) Antibody P40408.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human placenta tissue using PAK1/2 (Phospho-Ser199) antibody P40408 (left)or the same antibody preincubated with blocking peptide (right).