中文 
别名:gamma-PAK; PAK65; PAKI; PAK 2;应用:IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.Martin G.A., EMBO J. 14:1970-1978(1995)The MGC Project Team; Genome Res. 14:2121-2127(2004)Olsen J.V., Cell 127:635-648(2006) |
| Specification | |
|---|---|
| Aliases | gamma-PAK; PAK65; PAKI; PAK 2; |
| Entrez GeneID | 5062; |
| Swissprot | Q13177 |
| WB Predicted band size | 58kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of Serine 197(T-R-S(p)-V-I) derived from Human PAK2. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| IHC | 1/50-1/100 |
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PAK2 (Phospho-Ser197) antibody P40451 (left)or the same antibody preincubated with blocking peptide (right). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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