Rabbit Polyclonal Antibody to PARD3

包装: 1G|100G|500G|1KG|100KG

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别名:Partitioning-defective 3 homolog; PARD-3; PAR-3; Atypical PKC isotype-specific-interacting protein; ASIP
应用:WB,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions By similarity. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.Joberty G., Nat. Cell Biol. 2:531-539(2000).Fang C.M., Cell Res. 11:223-229(2001).Kohjima M., Biochem. Biophys. Res. Commun. 299:641-646(2002).

Description

Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions By similarity. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.Joberty G., Nat. Cell Biol. 2:531-539(2000).Fang C.M., Cell Res. 11:223-229(2001).Kohjima M., Biochem. Biophys. Res. Commun. 299:641-646(2002).

Specification
Aliases	Partitioning-defective 3 homolog; PARD-3; PAR-3; Atypical PKC isotype-specific-interacting protein; ASIP
Entrez GeneID	56288;
Swissprot	Q8TEW0
WB Predicted band size	151kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human PARD3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
ICC	1/100-1/500

	Western blot analysis of extracts from COLO205 cells, using PARD3 antibody P42064.
	Immunofluorescence analysis of HepG2 cells, using PARD3 antibody P42064.