Rabbit Polyclonal Antibody to Parp6 (C-term 503)

包装: 1G|100G|500G|1KG|100KG

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别名:Poly [ADP-ribose] polymerase 6, PARP-6, ADP-ribosyltransferase diphtheria toxin-like 17, ARTD17, PARP6
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

Description

Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

Specification
Aliases	Poly [ADP-ribose] polymerase 6, PARP-6, ADP-ribosyltransferase diphtheria toxin-like 17, ARTD17, PARP6
Entrez GeneID	56965
Swissprot	Q2NL67
WB Predicted band size	71.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This Parp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-538 amino acids from the C-terminal region of human Parp6.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Application
WB	1/1000

	Western blot analysis of Parp6 (arrow) using rabbit polyclonal Parp6 Antibody (C-term) (Cat. #P30242). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Parp6 gene.
	Parp6 Antibody (C-term) (Cat. #P30242) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Parp6 antibody detected the Parp6 protein (arrow).