Rabbit Polyclonal Antibody to PBOV1

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别名:UC28; UROC28; dJ171N11.2
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
UROC28, also known as PBOV1 (prostate and breast cancer overexpressed 1) or UC28, is a 135 amino acid cytoplasmic and nuclear protein that is expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary and peripheral blood leukocytes. UROC28 is up-regulated in prostate, breast and bladder cancer, and is thereby considered a useful target for diagnosis and treatment of these cancers. UROC28 is encoded by a gene located on human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Description

UROC28, also known as PBOV1 (prostate and breast cancer overexpressed 1) or UC28, is a 135 amino acid cytoplasmic and nuclear protein that is expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary and peripheral blood leukocytes. UROC28 is up-regulated in prostate, breast and bladder cancer, and is thereby considered a useful target for diagnosis and treatment of these cancers. UROC28 is encoded by a gene located on human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Specification
Aliases	UC28; UROC28; dJ171N11.2
Swissprot	Q9GZY1
WB Predicted band size	16 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide of human PBOV1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/200-1/1000
IHC	1/10-1/50
ELISA	1/5000-1/10000

	Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal intestines tissue lysate, Primary antibody: P12026(PBOV1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
	The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12026(PBOV1 Antibody) at dilution 1/20. (Original magnification: ×200)