中文 
别名:Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl
| Description |
|---|
| This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5′ UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq]. |
| Specification | |
|---|---|
| Aliases | Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC |
| Entrez GeneID | 5091 |
| Swissprot | P11498 |
| WB Predicted band size | 129.6kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human PC. |
| Formulation | Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Application | |
|---|---|
| WB | 1/1000 |
| IHC | 1/100-1/500 |
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Anti-PC Antibody (N-term) at 1:1000 dilution + HepG2 whole cell lysate
Lysates/proteins at 20 µg per lane. Secondary Predicted band size : 130 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
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PC Antibody (N-term) (Cat. #P33607) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PC antibody detected the PC protein (arrow). |
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PC Antibody (N-term) (Cat. #P33607)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PC Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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