Rabbit Polyclonal Antibody to PDZD2

包装: 1G|100G|500G|1KG|100KG

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别名:PDZ domain-containing protein 2; PDZ domain-containing protein 3; Activated in prostate cancer protein; Processed PDZ domain-containing protein 2; PDZD2
应用:IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.Chaib H., Cancer Res. 61:2390-2394(2001).Nagase T., DNA Res. 4:141-150(1997).

Description

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.Chaib H., Cancer Res. 61:2390-2394(2001).Nagase T., DNA Res. 4:141-150(1997).

Specification
Aliases	PDZ domain-containing protein 2; PDZ domain-containing protein 3; Activated in prostate cancer protein; Processed PDZ domain-containing protein 2; PDZD2
Entrez GeneID	23037;
Swissprot	O15018
WB Predicted band size	300kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human PDZD2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
IHC	1/50-1/100
ICC	1/100-1/500

	Immunofluorescence analysis of HepG2 cells, using PDZD2 antibody P41862.
	Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using PDZD2 antibody P41862.