Rabbit Polyclonal Antibody to PEA-15 (Phospho-Ser104)

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别名:PE15; PEA15; PED;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.Estelles A., J. Biol. Chem. 271:14800-14806(1996)Condorelli G., EMBO J. 17:3858-3866(1998)Wolford J.K., Gene 241:143-148(2000)

Description

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.Estelles A., J. Biol. Chem. 271:14800-14806(1996)Condorelli G., EMBO J. 17:3858-3866(1998)Wolford J.K., Gene 241:143-148(2000)

Specification
Aliases	PE15; PEA15; PED;
Entrez GeneID	8682;
Swissprot	Q15121
WB Predicted band size	19kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of Serine 104(I-P-S(p)-A-K) derived from Human PEA-15.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from COS cells treated with TNF using PEA-15 (Phospho-Ser104) Antibody P40389.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human heart tissue using PEA-15 (Phospho-Ser104) antibody P40389 (left)or the same antibody preincubated with blocking peptide (right).